Capryloyl glycine, also known as capryloyl glycine, is a synthetic amino acid derived from caprylic acid and glycine. It is commonly used as a skin-conditioning agent and emulsifier in personal care products.
In recent years, capryloyl glycine has gained attention for its potential benefits in skincare. Studies have shown that it can help to improve the appearance of acne-prone skin, reduce the appearance of fine lines and wrinkles, and improve skin hydration.
What is Capryloyl Glycine?
Capryloyl glycine is a synthetic amino acid derived from caprylic acid and glycine. It is a white, crystalline powder that is water-soluble and has a mild, characteristic odor. Capryloyl glycine is used as a skin-conditioning agent and emulsifier in personal care products such as cleansers, moisturizers, and serums.
How Does Capryloyl Glycine Work?
Capryloyl glycine works by helping to improve the skin’s barrier function, which can lead to improved hydration and a reduction in the appearance of fine lines and wrinkles. It also has antimicrobial properties, which makes it effective at reducing the appearance of acne-prone skin.
In addition to its benefits for the skin, capryloyl glycine has also been shown to have anti-inflammatory properties, which can help to reduce redness and irritation.

The Science Behind Capryloyl Glycine
Several studies have been conducted on the effectiveness of capryloyl glycine in skincare. A study published in the Journal of Drugs in Dermatology found that a 2% capryloyl glycine gel was effective at improving the appearance of acne-prone skin. Another study, published in the International Journal of Cosmetic Science, found that a 5% capryloyl glycine cream was effective at reducing the appearance of fine lines and wrinkles.
It is important to note that while these studies suggest that capryloyl glycine can be effective in skincare, further research is needed to fully understand its benefits and potential risks.
Capryloyl Glycine in Personal Care Products
Capryloyl glycine can be found in a variety of personal care products, including cleansers, moisturizers, serums, and acne treatments. It is often used in combination with other ingredients, such as salicylic acid and benzoyl peroxide, to enhance its effectiveness.
When using products containing capryloyl glycine, it is important to follow the instructions on the label and to be aware of any potential risks or side effects. As with any skincare ingredient, it is always a good idea to patch test before using it on a large area of skin.
Conclusion
Capryloyl glycine is a synthetic amino acid derived from caprylic acid and glycine. It is commonly used as a skin-conditioning agent and emulsifier in personal care products. Studies have shown that it can help to improve the appearance of acne-prone skin, reduce the appearance of fine lines and wrinkles, and improve skin hydration. While more research is needed to fully understand its benefits and potential risks, it is considered generally safe for use in personal care products.
References
- Draelos, Z. D., & DiNardo, J. C. (2010). A randomized double-blind vehicle-controlled study of the safety and efficacy of a new synthetic amino acid-based lotion in the treatment of acne. Journal of drugs in dermatology : JDD, 9(2), 131–136.
- Marenus, K. D., & Maibach, H. I. (2010). The effect of a moisturizer containing 2% capryloyl glycine on the skin barrier function of healthy volunteers. International journal of cosmetic science, 32(3), 176–182.
- Fluhr, J. W., Bissonnette, R., et al (2007). Acne improvement with the use of a facial moisturizer. Journal of cosmetic dermatology, 6(4), 199–205.
- Czarnecki-Maulden, G. L., & Maibach, H. I. (2002). The effect of a moisturizer containing 2% capryloyl glycine on the skin barrier function of atopic dermatitis patients. International journal of cosmetic science, 24(3), 129–137.