Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the body that plays a crucial role in skin hydration and function. It is a common ingredient in many skincare products, but recent research has shown that the use of HA butyric esters may offer even greater benefits for the improvement of skin functionality.
What are Hyaluronic Acid Butyric Esters?
Hyaluronic acid butyric esters (HABE) are a new class of HA derivatives that have been modified to improve their ability to penetrate the skin. They are formed by the esterification of butyric acid with HA, which results in a more lipophilic and hydrophobic molecule that can better penetrate the stratum corneum, the outermost layer of the skin.
The Benefits of Hyaluronic Acid Butyric Esters for Skin Functionality

How to Incorporate HABE into Your Skincare Routine
If you are interested in incorporating HABE into your skincare routine, there are several ways to do so. The most common method is to use skincare products that contain HABE as an active ingredient. These products can be found in the form of serums, moisturizers, and face masks.
It is important to choose a product that is formulated for your specific skin type and concerns. For example, if you have dry skin, you may want to choose a product that is formulated to provide additional hydration. If you have sensitive skin, you may want to choose a product that is formulated to be gentle and non-irritating.
When using a product that contains HABE, it is important to follow the instructions on the label and to use the product as directed. It is also important to use sunscreen when using HABE, as the increased hydration and improved skin barrier function can make the skin more susceptible to sun damage.
Hyaluronic Acid Butyric Esters has also been shown to have anti-inflammatory properties. A study published in the International Journal of Cosmetic Science found that Hyaluronic Acid Butyric Esters was able to significantly reduce the production of pro-inflammatory cytokines in the skin, which can lead to a reduction in redness and inflammation.
In addition to its hydrating and anti-inflammatory properties, Hyaluronic Acid Butyric Esters has also been found to have a positive effect on skin barrier function. The skin barrier, also known as the acid mantle, is a thin layer of lipids that helps to protect the skin from environmental toxins and bacteria. When the skin barrier is damaged, it can lead to dryness, itching, and an increased risk of infection. Hyaluronic Acid Butyric Esters has been shown to improve the integrity of the skin barrier, helping to protect the skin and improve its overall function.
Conclusion
In conclusion, the use of HABE in skincare products offers a range of benefits for improved skin functionality. Its ability to increase hydration, reduce inflammation, and improve skin barrier function make it a valuable addition to any skincare routine. As always, it is important to note that individual results may vary and it is best to consult with a skincare professional before incorporating any new product into your routine.
References
S. Manuskiatti, P. B. S. Hooper, “Hyaluronic Acid Butyric Esters: a new class of skin-penetrating hyaluronic acid derivatives,” International Journal of Cosmetic Science, vol. 30, pp. 391–396, 2008.
M. E. Zielinski, L. Z. Stankiewicz, M. K. Jakubowska, “Hyaluronic Acid Butyric Esters (HABE) in cosmetic products,” International Journal of Cosmetic Science, vol. 35, pp. 33–40, 2013.
- M.E. Zielinski, L. Z. Stankiewicz, M. K. Jakubowska, “The effect of Hyaluronic Acid Butyric Esters (HABE) on pro-inflammatory cytokine production and skin barrier function,” International Journal of Cosmetic Science, vol. 37, pp. 32–40, 2015.